Relationship between lipoprotein lipase gene polymorphism and hemorrhagic stroke in a Chinese population.

OBJECTIVE To investigate the relationship between lipoprotein lipase (LPL) gene polymorphism and cerebral hemorrhage in a Chinese population. METHOD This study was based on the case-control study, PCR-RELP and sequencing method were utilized for genotyping. LPL gene Hind III polymorphism was detected both in 300 patients with cerebral hemorrhage (CH group) and in 300 healthy control subjects (control group). Blood lipid level and blood glucose were detected at the same time. RESULT Our results showed that G allele frequency was significant lower in the CH group than that in the control group (OR=0.611; 95% CI: 0.427-0.876, P=0.001). We also found both GG (OR=0.543, 95% CI: 0.233-0.988; P=0.041) and TG (OR=0.609, 95% CI: 0.387-0.959, P=0.032) genotype were frequent in the control group than that in the CH group. TG level of the groups who carry TT genotype were much higher than that of the groups carrying TG+GG genotype (P<0.05). By means of adjusting age, hypertension and hyperglycemia, logistic multivariate regression analysis revealed that LPL Hind III G allele might be a protective factor (OR=0.601, 95% CI: 0.231-0.876; P=0.001) in the present study. CONCLUSION It is suggested that LPL Hind III G allelic mutation might be a protective factor against cerebral hemorrhage disease in Chinese population.